汇报标题(中文)：生物响应型分子成像资料
汇报标题(英文)：Molecular Imaging Agents Responsive to In Vivo Signals
汇报人姓名：Andrew K. Whittaker
汇报人单元：澳大利亚昆士兰大学
汇报功夫：2014-10-13 10:00
汇报地址：校本部东区资料楼520
主办：资料学院
汇报人简介(中文)：Andrew Whittaker教授现任澳大利亚钻研理事会资深教授钻研员，是澳大利亚昆士兰大学生物工程和纳米技术钻研所（AIBN）及高级成像中心（CAI）的学术带头人。他致力于钻研高档高分子化学以解决科技和健全领域等沉要问题。目前重要钻研的利用领域蕴含：1）用于病变组织鉴别、药物开释、组织再生的聚合物和纳米资料；2）用于先进光刻技术的聚合物；3）现代核磁共振及成像的资料表征。他的团队在化学合成、物理化学和资料表征等领域均有很高造诣。目前他辅导着一支约40名钻研人员的课题组，钻研领域涉及高分子化学的多个方面。Whittake教授是太平洋高分子结合学会的前任主席、澳大利亚皇家化学汇聚合物部的前任主席、澳大利亚高分子学会的主席，同时也是多个国际科学委员会的成员。他的多多奖项中蕴含2013年和2014年由中国表国专家局核准的高端表国专家项目。在从前的十年里他共获得超过4000万澳元（大于2亿人民币）的科研经费，在国际驰名杂志公开颁发文章超过265篇。总之，Andrew Whittaker教授已经在高分子化学和核磁共振领域工作了25年之多。
汇报内容简介：Recently there has been intense interest in the development of fluorinated molecules to allow tracking of therapeutic particles and cells in vivo. The motivation for this is the very high selectivity of the 19F imaging experiment, since unlike in 1H NMR imaging, the body does not contain a confounding fluorine background signal. In principle therefore, if doubly-tuned MRI coils are available, highly-selective 19F images can be superimposed on high-resolution anatomical 1H images, thus allowing tracking of suitably-labelled cells or biomarker molecules. In this presentation I will describe the current status of magnetic resonance imaging agents with a focus on polymeric agents. This will define the motivation for the development of new partly-fluorinated copolymers which have outstanding potential as 19F MRI imaging agents.1,2,3 In this paper we describe the development of several new classes of polymeric 19F MRI agents with precisely controlled architecture and functionality. In the first generation of materials, amphiphilic copolymers PAA-b-p(nBA-stat-TFE(M)A) were prepared by ATRP of trifluoroethyl (meth)acrylate and n-butyl acrylate using PtBA as macroinitiator, followed by acidolysis in TFA/DCM. The block copolymers were micellized by slow addition of water from various solvents. MRI properties were measured for all systems and the relationship between structure and performance determined.1,3 The second generation materials2,4 arising from these studies are hyperbranched analogues constructed from similar monomers and made highly branched by incorporation of a crosslinking monomer during RAFT (or ATRP) synthesis. Excellent imaging performance was observed. More recently we have developed a series of linear, branched and star molecules incorporating the monomers N,N-dimethylaminoethyl methacrylate and poly(ethylene glycol) methacrylate which are responsive to external stimuli, for example local temperature, pH or ionic strength.5-7 Details of application of these systems to a range of important diseases, such as melanoma, prostate cancer and malignant glioma will be presented.
